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Mercury as a single element is highly poisonous metal but in dental amalgam, it is made in an alloy composed of copper, tin, and silver. Very little mercury vapor is released from the dental amalgam. For most patients, there are no known harmful effects caused by the mercury in amalgam fillings. For those who have high exposure to mercury, such as people who work in industrial settings, the severity of mercury poisoning depends on the amount of exposure and the duration. However, in low level mercury exposure associated with dental amalgam, the relationship between the possible effects and the duration and level of exposure is still unknown. Dental amalgam is still the most affordable and most durable of all dental fillings, and further research is still being done to arrive at definite scientific answers.

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